Many owners encounter this question: should they keep their cats in a cage when they are home alone? Many working people choose to let their cats roam freely. Although cats may occasionally damage the plants at home, life outside the cage makes them happier. 
We see many cats and dogs in pet stores, all kept in cages. The cats don't seem to have any bad reactions. In fact, cats can live in small spaces, but this kind of life is not suitable for cats kept as pets. If you are going out for a short time, you might as well trust your cat and let it roam freely at home.
If no one will be home for two days, you can leave the cat alone so it won't feel burdened. If possible, ask a cat-loving friend to take care of it once a day, feeding it and cleaning its litter box. If that's not possible, prepare plenty of food and water for the cat before leaving, placing them in several locations, and also prepare two litter boxes.
Try to avoid taking your cat out in the dead of winter or the sweltering heat. When you go out, you'll close the windows and turn off the air conditioning, leaving your cat unbearably hot in a stuffy home, and you'll also worry about their food spoiling. Conversely, the harsh winter cold can be a concern for your cat's health. Try not to close the outer windows of windows that let in sunlight; this will at least keep the house warmer during the day, making things more comfortable for your cat. Also, spread out blankets so they can crawl inside when they're cold.