When a large cat hisses at a kitten, it should be stopped immediately. Hissing usually indicates hostility and an intention to attack, a sign of a cat's strong territorial instincts. If not stopped promptly, it could lead to a fight and injury.

Cat owners can reduce the likelihood of fighting by distracting their cats, using treats as bait, and creating a harmonious environment for them to coexist, allowing them to gradually become familiar with each other and get along happily. In addition, when raising multiple cats, it is recommended to provide more resources such as litter boxes and water fountains to prevent them from fighting over limited resources.