The main difference between chubby cheeks and obesity in cats is that chubby cheeks refer to the gradual increase of flesh on the sides of a cat's face, forming a round, chubby face, while obesity is a generalized increase in a cat's weight, not just in the face.

Cats with chubby cheeks typically have round, chubby faces, appearing larger and more rounded, often referred to as "bun faces." If the cat's body size remains within the normal range, without significant weight gain or excess fat, this indicates that the cat's chubby cheeks are a sign of chubby cheeks rather than obesity.