Durian does not pose a significant health risk to cats. However, some cats are particularly sensitive to its smell, and may experience vomiting or fainting after inhaling it. Furthermore, excessive durian consumption can lead to symptoms such as fever, constipation, and diarrhea in cats.

Durian has seeds that are quite large. These seeds contain cyanide, and if a cat accidentally eats them, it may be poisoned. Furthermore, because the seeds are so large, if a cat ingests them, it may experience gastrointestinal obstruction.