When used correctly and according to the instructions or veterinarian's recommended dosage, flea medication specifically formulated for cats usually does not harm them. However, if the wrong medication is chosen, the dosage is too high, or the method of application is incorrect, it may lead to poisoning or other adverse reactions in the cat.

In addition, some non-cat-specific flea medications, such as flea collars and flea powders, may be harmful to cats because they may contain ingredients that are harmful to cats, such as pyrethroids. Exercise caution when choosing and using flea medications, and follow the advice of a veterinarian or other professional.