Cats with one blue eye and one yellow eye do not have a specific breed; this can occur in any breed. It is commonly known as "heterochromia" or "odd-eyed," and it is mainly determined by the genes that control eye color.

For example, the Lion Cat is a typical heterochromatic cat, with both blue and yellow eyes. Its fur is usually white, and it has a gentle temperament. Its appearance resembles a Persian cat and also bears a lion's mark, hence the name Lion Cat. Due to its low reproductive rate, purebreds are rare, making it one of China's famous cat breeds.