A mother cat may feel sad about her kittens leaving, depending on the emotional bond between them and the mother cat's personality. Some mother cats may show signs of loss, anxiety, or sadness after their kittens leave, while others may remain calmer and more accepting.

If a mother cat and kittens have developed a very close bond, the kittens' departure can cause significant psychological trauma to the mother cat. The mother cat may frequently search for the kittens or show little interest in other family members or new pets. In such cases, seeking professional veterinary counseling or therapy can help the mother cat cope with grief and anxiety.