Cats may experience motion sickness on long car journeys. Motion sickness is an discomfort caused by problems with balance and inner ear perception. Some cats may exhibit symptoms of motion sickness during long car trips, such as:

Vomiting: This is a common symptom of motion sickness.
Drooling: Increased oral secretions.
Restlessness: May manifest as anxious and uneasy behavior.
Unusual vocalizations: making unusual vocalizations.
Listless: appearing tired and lethargic.